Colon cancer: RFA-Radio Frequency Ablation for inoperabele liver tumors from colon cancer turns out effective and even potentially a healing treatment, says Dutch long year study. 24% lived after 8 years. Article posted 25 January 2012
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25 January 2012: Br J Radiol. Source: 2011 Jun; 84 (1002): 556-65. Epub 2010 Dec 15. Thanks to doctor from the VUMC
More and more studies are showing that RFA-Radio Frequency Ablation freely also for liver tumors from colon cancer can be a life-prolonging treatment. Last week I was visiting the VUMC and if a RFA treatment of a kidney cancer patient attending. Later I'll put a write-up on the site. The doctor who sent me a few abstract artists, invited me. Here the first but there are even more.
From the following study shows that a RFA treatment carried out at inoperabele darmkanker patients with liver tumors and in some cases even life-sustaining worked for "healing" (5 years clinical tumor free). Results from a study conducted at 100 patients were as follows:
TARGET: The long term results and prognostic factors radiofrequency ablation (RFA) voor inoperabele colorectal liver metastases (CRLM) in a centre with more than 10 years experience were retrospective analyzed.
METHODS: A total of100patients with inoperablecolorectalliver metastases(CRLM) (size0.2-8.3cmwith an average size of 2.4cm) underwent atotal of126RFA treatments (237lesions-tumors).The averagefollow-up time29 wasmonths (range6-93months). Tumor characteristics(size, number andlocation), procedureattributes (orpercutaneousintra-operativeapproach) and thelarge and smallcomplicationswere carefullyrecorded.Local control, the averagesurvival time andrelapsefree andoverall survivalwere statisticallyanalyzed.
RESULTSg : there werea direct behandleings related deathsobserved. Serious complications occurred at 8 patients. A local relapse on the RFA treatment place appeared at class = "hps" > 12.7% (n = 30/237) for to come, for tumors with a diameter of less than 3 cm, 3-5 cm and larger than 5 cm, that percentage were respectively 5.6% (n = 8/ 143), 19.5% (n = 15 / 77) and 41.2% (n = 7/17). Centrally located tumors came back more often than tumors in the peripheral areas (exteriors), at 21.4% (n = 21/98) versus 6.5% (n = 9 /139), respectively, p = 0,009. Including extra treatments for recurring tumors when possible, became a lakale tumor control reaches 93%. The average survival duration of the patients who have been treated with RFA was 56 (95% confidence interval (BI) 45-67) months. Overall 1 -, 3 -, 5 - en 8-jaars survival of RFA group was 93%, 77%, 36% and 24%, respectively.
CONCLUSIONS:RFA -Radio Frequency ablation forCRLMinoperabeleisasafe, effectiveand potentiallycurative treatment class = "hps" > s option;the long termresults aresimilar to that ofprevious studies involving surgical resection could take place.Factors determining for a successful treatment tumorsize,location and thenumber of tumors.
The original abstract Below if you want to have the full study report., we can send this digitally. Send ona but an email: redactie@kanker-actueel.nl
RFA is a safe, effective and CRLM unresectable for potentially curative treatment option; the long-term results are comparable with those of previous investigations employing surgical resection. Factors determining success are lesion size, the number of lesions and location
Long-term results of radiofrequency ablation for unresectable colorectal liver metastases: a potentially curative intervention.
Source
Department of Radiology, VU University Medical Centre, De Boelelaan 1117, Amsterdam, the Netherlands. a.vantilborg@vumc.nl
Abstract
OBJECTIVE:
The long-term results and prognostic factors of radiofrequency ablation (RFA) for unresectable colorectal liver metastases (CRLM) in a single centre with > 10 years of experience were retrospectively analysed.
METHODS:
A total of 100 patients with unresectable colorectal liver metastases (CRLM) (size 0.2-8.3 cm; mean 2.4 cm) underwent a total of 126 RFA sessions (237 lesions). The mean follow-up time was 29 months (range 6-93 months). Lesion characteristics (size, number and location), procedure characteristics (percutaneous or intra-operative approach) and major and minor complications were carefully noted. Local control, mean survival time and recurrence-free and overall survival were statistically analysed.
RESULTS:
No direct procedure-related deaths were observed. Major complications were present in eight patients. Local recurrence was 12.7% RFA site (n = 30/237); for tumour diameters or < 3 cm, 3-5 cm and > 5 cm, recurrence was 5.6% (n = 8/143), 19.5% (n = 15/77) and 41.2% (n = 7/17), respectively. Centrally located lesions more often than peripheral ones, recurred at 21.4% (n = 21/98) vs 6.5% (n = 9/139), respectively, p = 0.009. Including additional treatments for recurring lesions when feasible, lesion-based local control reached 93%. The mean survival time from RFA was 56 (95% confidence interval (CI) 45-67) months. Overall 1-, 3-, 5-and 8-year survival from RFA was 93%, 77%, 36% and 24%, respectively.
CONCLUSIONS:
RFA is a safe, effective and CRLM unresectable for potentially curative treatment option; the long-term results are comparable with those of previous investigations employing surgical resection. Factors determining success are lesion size, the number of lesions and location.
- PMID:
- 21159807
- [PubMed-indexed for MEDLINE]
